CP 376395

CAS No. 175140-00-8

CP 376395( —— )

Catalog No. M17373 CAS No. 175140-00-8

CP 376395 is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 In Stock
5MG 95 In Stock
10MG 174 In Stock
25MG 365 In Stock
50MG 531 In Stock
100MG 773 In Stock
500MG 1575 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    CP 376395
  • Note
    Research use only, not for human use.
  • Brief Description
    CP 376395 is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.
  • Description
    CP 376395 is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.(In Vitro):CP 376395 fully antagonizes oCRF-stimulated adenylate cyclase activity in rat cerebral cortex and at human CRF1 receptors with an apparent Ki value of 12 nM, indicating antagonist functional activity. It is highly selective for the human CRF1 receptor subtype; affinity for the CRF2 receptor is >10000 nM. It shows affinities greater than 1 μM against 40 neurotransmitter receptor and ion channels.(In Vivo):In the CNS, systemically administered CP 376395 blocks the effects of both exogenous and endogenous CRF. Pretreatment with CP 376395 reverses the excitation of locus coeruleus neurons induced by icv CRF (3 μg) with an ID50 of completely blocked the enhanced startle response induced by icv CRF (1 μg) at 17.8 mg/kg, p.o. and partially blocked at 10 mg/kg, p.o. without significantly altering baseline startle. The attenuation of fear-potentiated startle is statistically significant at lower doses (0.32-3.2 mg/kg, p.o., with 62-83% blockade) and completely reversed by CP 376395 at 10 mg/kg, p.o.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male B6 mice (n=8-9 per group)Dosage:0.0, 10.0, or 20.0 mg/kg Administration:Intraperitoneally.Result:Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CRF1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    175140-00-8
  • Formula Weight
    326.48
  • Molecular Formula
    C21H30N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 306.30 mM ;H2O : < 0.1 mg/mL
  • SMILES
    CCC(CC)NC1=CC(=NC(=C1C)OC2=C(C=C(C=C2C)C)C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92.
molnova catalog
related products
  • Amcasertib

    A small-molecule inhibitor that inhibits Nanog and other CSC (cancer stem cells) pathways by targeting kinases.

  • Purine

    Purine is a heterocyclic aromatic organic compound consisting of a pyrimidine ring fused to an imidazole ring.

  • Scutebarbatine A

    Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2.