CP 376395
CAS No. 175140-00-8
CP 376395( —— )
Catalog No. M17373 CAS No. 175140-00-8
CP 376395 is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 43 | In Stock |
|
5MG | 95 | In Stock |
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10MG | 174 | In Stock |
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25MG | 365 | In Stock |
|
50MG | 531 | In Stock |
|
100MG | 773 | In Stock |
|
500MG | 1575 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameCP 376395
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NoteResearch use only, not for human use.
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Brief DescriptionCP 376395 is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.
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DescriptionCP 376395 is an effective and specific Corticotropin-releasing factor 1 (CRF1) receptor antagonist.(In Vitro):CP 376395 fully antagonizes oCRF-stimulated adenylate cyclase activity in rat cerebral cortex and at human CRF1 receptors with an apparent Ki value of 12 nM, indicating antagonist functional activity. It is highly selective for the human CRF1 receptor subtype; affinity for the CRF2 receptor is >10000 nM. It shows affinities greater than 1 μM against 40 neurotransmitter receptor and ion channels.(In Vivo):In the CNS, systemically administered CP 376395 blocks the effects of both exogenous and endogenous CRF. Pretreatment with CP 376395 reverses the excitation of locus coeruleus neurons induced by icv CRF (3 μg) with an ID50 of completely blocked the enhanced startle response induced by icv CRF (1 μg) at 17.8 mg/kg, p.o. and partially blocked at 10 mg/kg, p.o. without significantly altering baseline startle. The attenuation of fear-potentiated startle is statistically significant at lower doses (0.32-3.2 mg/kg, p.o., with 62-83% blockade) and completely reversed by CP 376395 at 10 mg/kg, p.o.
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In Vitro——
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In VivoAnimal Model:Male B6 mice (n=8-9 per group)Dosage:0.0, 10.0, or 20.0 mg/kg Administration:Intraperitoneally.Result:Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorCRF1
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Research Area——
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Indication——
Chemical Information
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CAS Number175140-00-8
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Formula Weight326.48
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Molecular FormulaC21H30N2O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 306.30 mM ;H2O : < 0.1 mg/mL
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SMILESCCC(CC)NC1=CC(=NC(=C1C)OC2=C(C=C(C=C2C)C)C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92.
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